Test Findings
 

Anti-TPO Antibodies

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Overview

  • Antithyroperoxidase (TPO) antibodies are directed against thyroperoxidase, an enzyme involved in thyroid hormone production.

    • Significance

    • Antithyroperoxidase enzymes are present in 90-100% of patients with chronic autoimmune (Hashimoto's) thyroiditis, though are also present in other thyroid diseases.
  • Antithyroperoxidase antibodies are not usually required in the diagnosis of primary hypothyroidism as almost all cases are due to Hashimoto's thyroiditis.
  • This test is useful for predicting the risk of progression to overt hypothyroidism in patients with subclinical hypothyroidism.
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