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Test Findings

Anti-CCP Antibodies



  • Anti-CCP antibodies are autoantibodies to cyclic citrullinated peptide, which is generally present in rheumatoid arthritis.
      • Normal Range

      • <10 U/mL
    • Causes of Elevated Anti-CCP Titre

    • Rheumatoid arthritis
    • Psoriatic arthritis
    • Sjögren’s syndrome
    • Inflammatory myopathies
    • Active TB
    • Pearls

    • 70% sensitive and 95% specific for rheumatoid arthritis, therefore a negative test does not rule out RA
    • Generally interpreted with rheumatoid factor as the two tests together are more predictive
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