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Wheeze

Overview

  • Wheezing is an unpleasant symptom that often occurs in patients with exacerbations of asthma, COPD, heart failure or allergies. Ask about possible precipitants for the patient's wheeze, and if in doubt consider rarer causes such as Churg-Strauss or carcinoid syndrome.

Aetiology

    • Causes of Wheeze

    • Obstructive lung disease - asthma, COPD
    • Left ventricular failure (pulmonary oedema)
    • Allergy (angioedema)
    • Aspiration
    • Bronchial / tracheal obstruction - foreign body, tumour, stenosis
    • Carcinoid syndrome
    • Churg-Strauss syndrome
    • Allergic bronchopulmonary aspergillosis (ABPA)
    • Asthma Triggers

    • Environmental - pollen, tobacco smoke, pollutants
    • Medications - beta blockers, ACE inhibitors, NSAIDs
    • Exercise
    • Stress
    • Respiratory infections
    • Gastroesophageal reflux

History of Presenting Complaint

    • Onset

      When the wheeze started, and under what circumstances.
    • Onset post eatingAllergy, aspiration or reflux (asthmatics)
    • Onset post new medicationPotential allergic drug reaction
    • Associated Symptoms

      Whether the wheeze is associated with any other symptoms.
    • Associated with shortness of breathNonspecific symptom of cardiorespiratory disease
    • Associated with paroxysmal nocturnal dyspnoeaSuggestive of heart failure
    • Fevers and coryzal symptoms / cough in an asthmaticSuggestive of infective exacerbation
    • Associated with haemoptysisConcerning for lung cancer
    • Exacerbating Factors

      Whether there is anything that triggered the wheeze or makes it worse.
    • Worse on lying downSuggestive of heart failure or reflux (asthmatics)
    • Exacerbated by environmental triggersSuggestive of asthma / allergies
    • Alleviating Factors

      Whether there is anything that relieves the wheeze.
    • Relieved with bronchodilatorSuggestive of asthma / COPD
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Associated Diseases
BETA

Cardiovascular
Immunology
Oncology
Respiratory
Bronchial Disease
Trauma

Associated Drugs
BETA

Anti-HER2
Trastuzumab-Emtansine
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