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Purpura

Overview

  • Purpura, or bruising, may develop in the context of trauma, coagulopathy, platelet deficiency / dysfunction, or vascular disorders.
    • Look For

    • Red / purple lesions that do not blanch with pressure. May be present over the head, arms, legs, chest or abdomen.
    • Interpretation

    • Petechiae - flat lesions, <4mmThrombocytopaenia / abnormal platelet function, DIC
    • Ecchymoses - flat lesions, >4mmTrauma, DIC, coagulation disorders, senile purpura
    • Palpable purpura associated with arthralgia, abdominal pain and renal diseaseHenoch-Schönlein purpura
    • Causes of Purpura

    • Trauma

    • Platelet Disorders

    • Idiopathic thrombocytopaenic purpura (ITP)
    • Thrombotic thrombocytopaenic purpura (TTP)
    • Disseminated intravascular coagulation (DIC)
    • Bone marrow failure - aplastic anaemia, leukaemia, chemotherapy
    • Platelet sequestration - splenomegaly, haemangioma
    • Haemolytic-uraemic syndrome
    • Disorders of Coagulation

    • Factor deficiencies - haemophilia, Von Willebrand disease
    • Vitamin K deficiency - malabsorption, poor diet
    • Anticoagulants
    • Vascular Disorders

    • Connective tissue diseases - Ehlers-Danlos, scurvy
    • Infection - mengingococcal, streptococcal, viral
    • Henoch-Schönlein purpura
    • Senile purpura
    • Steroids
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Associated Diseases
BETA

Haematology
Coagulation Disorders
Bleeding Disorders
Thrombotic Microangiopathies
Red Cell Disorders
Haematologic Malignancy
Nutrition & Metabolic
Other

Associated Drugs
BETA

Low Molecular Weight Heparins
Aspirin
Anticoagulants
Antiplatelets
Fibrinolytics
Systemic Corticosteroids
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