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Resp History

The Tuberculosis History

March 4th, 2023
On this page:Management


Tuberculosis is the disease caused by the bacteria Mycobacterium tuberculosis, and may affect almost any organ in the body resulting in a wide range of clinical presentations. In patients with a history of tuberculosis, it is important to understand the risk factors, natural history and past treatment of disease.
  • Ask About

  • Diagnosis - symptoms, affected organs, how TB was diagnosed
  • Risk factors - immunosuppression, alcohol, malnutrition, diabetes
  • Travel history - immigrant status, recent travel
  • Management - which medications over how long
  • Public health implications - exposure to contacts, family
  • Risk Factors for Tuberculosis

  • Immunosuppression - HIV, post transplant, autoimmune disease
  • Alcohol abuse
  • Malnutrition
  • Diabetes
  • Smoking


  • Management Options

  • Latent TB

  • Isoniazid
  • Rifampicin
  • Active TB

  • First line (HRZE) - isoniazid, rifampicin, pyrazinamide and ethambutol
  • Other options - amikacin, capreomucin, moxifloxacin, linezolid, cycloserine, clofazimine, meropenem, augmentin
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