Drugs: Megaloblastic Anaemia
February 15th, 2021
Overview
Drugs that Can Cause Megaloblastic Anaemia
Interference with DNA Synthesis
- Folate antagonists - methotrexate, trimethoprim
- Purine analogues - azathioprine, 6-mercaptopurine, allopurinol, cladribine, fludarabine
- Pyramidine antagonists - 5-fluorouracil, cytarabine, gemcitabine, capecitabine
- Anticonvulsants - valproate, phenytoin
- Reverse transcriptase inhibitors - abacavir, emtricitabine, entacavir, lamivudine, zidovudine, tenofovir, efavirenz
Malabsorption of B12 / Folate
- Colchicine
- Isoniazid
- Metformin
- Cholestyramine
- Proton pump inhibitors
- Histamine 2 receptor antagonists
Other
- Ethanol
- Sulfasalazine
- Nitrous oxide
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