Autologous Stem Cell Transplant
February 15th, 2021
Overview
An autologous stem cell transplant refers to the process of mobilising and collecting a patient's stem cells, providing chemotherapy to deplete the bone marrow, and then retransfusing their stem cells. This process is less complex and has less potential side effects than an allogeneic stem cell transplant.
Ask About
- Peritransplant history - when the transplant was done, indication, mobilisation, conditioning
- Complications
- Post-transplant management - infective prophylaxis
- Prognosis
Peritransplant History
Ask About
- When
- Indication
- Stem cell mobilisation - using G-CSF or chemotherapy + G-CSF
- Conditioning - e.g. melphalan, BEAM
Indications for Autologous Stem Cell Transplant
- Multiple myeloma
- Relapsed / refractory lymphoma
- Certain autoimmune diseases - e.g. multiple sclerosis, scleroderma
Complications
Complications of Autologous Stem Cell Transplant
- Mucositis
- Infections
- Bone marrow suppression
- Sinusoidal obstructive syndrome (jaundice, hepatomegaly, fluid retention)
- Secondary myelodysplasia / acute myeloblastic leukaemia
Post-Transplant Management
Management Strategy
- Transfusion support
- Infective prophylaxis - e.g. bactrim, valaciclovir, fluconazole
- Vaccinations
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