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Haem History

Autologous Stem Cell Transplant

February 15th, 2021


An autologous stem cell transplant refers to the process of mobilising and collecting a patient's stem cells, providing chemotherapy to deplete the bone marrow, and then retransfusing their stem cells. This process is less complex and has less potential side effects than an allogeneic stem cell transplant.
  • Ask About

  • Peritransplant history - when the transplant was done, indication, mobilisation, conditioning
  • Complications
  • Post-transplant management - infective prophylaxis
  • Prognosis

Peritransplant History

  • Ask About

  • When
  • Indication
  • Stem cell mobilisation - using G-CSF or chemotherapy + G-CSF
  • Conditioning - e.g. melphalan, BEAM
  • Indications for Autologous Stem Cell Transplant

  • Multiple myeloma
  • Relapsed / refractory lymphoma
  • Certain autoimmune diseases - e.g. multiple sclerosis, scleroderma


  • Complications of Autologous Stem Cell Transplant

  • Mucositis
  • Infections
  • Bone marrow suppression
  • Sinusoidal obstructive syndrome (jaundice, hepatomegaly, fluid retention)
  • Secondary myelodysplasia / acute myeloblastic leukaemia

Post-Transplant Management

  • Management Strategy

  • Transfusion support
  • Infective prophylaxis - e.g. bactrim, valaciclovir, fluconazole
  • Vaccinations
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