Basic History
 

Adverse Drug Reactions

 
 
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Overview

    • Ask About

      Any reactions to medications.
    • What specific drug they have had a reaction to
    • What happens when they take the drug in question
    • How long after exposure to the drug the reaction began
    • How severe the reaction was
    • Whether the reaction resolved after cessation or dose-reduction of the drug
    • When this reaction first / last happened
    • Significance

    • Generally, avoid the drug in question
    • Not all adverse drug reactions are absolute contraindications - e.g. many medications cause nausea / vomiting
    • Not all adverse drug reactions are true - they may be misinterpretations
    • Types of Adverse Drug Reaction

    • Dose-related - narrow therapeutic index; generally improve with reduction in dose (may be required in renal or hepatic dysfunction)
    • Idiosyncratic - genetic susceptibility that is not dose-related
    • Allergic - occurs after sensitization
 
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