Cardio History
 

Hyperlipidaemia

 
 
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Overview

    • Ask About

    • Diagnosis - when diagnosed, primary / secondary, lipid results
    • Management - lifestyle changes, medications
    • Complications - atherosclerotic complications, NAFLD
    • Causes of Hyperlipidaemia

    • Primary

    • Familial lipoprotein lipase deficiency
    • Familial hypercholestolaemia
    • Familial combined hyperlipidaemia
    • Familial dysbetalipoproteinaemia
    • Familial hypertriglyceridaemia
    • Secondary: Predominantly LDL

    • Hypothyroidism
    • Cholestatic liver disease
    • Nephrotic syndrome
    • Secondary: Predominantly TAGs

    • Obesity
    • Diabetes
    • Alcohol abuse
    • Chronic kidney disease
    • Drugs - corticosteroids, antipsychotics, immunosuppressants, protease inhibitors, oral contraceptive pill, hormone replacement therapy
    • Pregnancy

Complications

    • Complications of Hyperlipidaemia

    • Atherosclerosis

    • Ischaemic heart disease
    • Ischaemic stroke
    • Erectile dysfunction
    • Peripheral vascular disease
    • Other

    • Non-alcoholic fatty liver disease

Management

    • Heart Foundation Lipid Targets

    • Total cholesterol: <4.0
    • LDL cholesterol: <2.0 (<1.8 if very high risk)
    • HDL cholesterol: >1.0
    • Triglycerides: <2.0
    • Management Options

    • Non-Pharmacologic

    • Dietary changes
    • Fish oil supplementation
    • Exercise
    • Alcohol avoidance
    • Smoking cessation
    • Pharmacologic

    • Statins - atorvastatin, pravastatin, rosuvastatin, simvastatin
    • Fibrates - fenofibrate, gemfibrozil
    • Ezetimibe
    • PCSK-9 inhibitors - alirocumab
Last updated on May 5th, 2019
 
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