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Upper Limb Neuro
 
 

Peripheral Polyneuropathy

 
 
 
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Overview

Peripheral polyneuropathy presents with motor, sensory or mixed deficits affecting multiple (usually symmetrical) nerve distributions, without a clear pattern of involvement affecting a nerve root or peripheral nerve distribution.
  • Signs of Peripheral Polyneuropathy

  • Lower motor neuron weakness affecting multiple nerve distributions
  • Sensory loss affecting multiple nerve distributions
  • Causes of Peripheral Polyneuropathy

  • Primarily Sensory

  • Diabetes mellitus
  • Vitamin deficiency - B12, pyridoxine
  • Hypothyroidism
  • Sarcoidosis
  • Paraneoplastic syndrome
  • Vasculitis - rheumatoid arthritis, polyarteritis nodosa, SLE
  • Protein-related - monoclonal gammopathy, amyloidosis, cryoglobulinaemia
  • Infection - lyme disease, HIV neuropathy, leprosy
  • Drugs - ethambutol, platinum-based chemotherapy, taxanes, vinca alkaloids
  • Primarily Motor

  • Guillain-Barre syndrome
  • Chronic inflammatory demyelinating polyneuropathy (CIDP)
  • Motor neurone disease
  • Multifocal motor neuropathy with conduction block
  • Polio
  • Sensorimotor

  • Alcohol
  • Charcot-Marie-Tooth
  • Drugs - amiodarone, lithium, nitrofurantoin
  • Toxins - heavy metals, organophosphates
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