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Vincristine

  •  
    IV
    Vincristine
    Oncovin 
    • Mechanism of Action
    • Inhibits cell proliferation by preventing polymerization of tubulin into microtubules.

Clinical Use

    • Indication
    • Certain solid organ and haematologic malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Neurotoxicity – numbness / paraesthesia / weakness
    • Leukopaenia / anaemia / thrombocytopaenia
    • Nausea / vomiting / constipation / paralytic ileus
    • Alopecia

Associated Adverse Effects
BETA

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