Vinblastine

• Mechanism of Action
• Inhibits cell proliferation by preventing polymerization of tubulin into microtubules.

Clinical Use

• • Indication
  • Certain solid organ and haematologic malignancies, as guided by cancer specialists and local guidelines.
• • Adverse Effects
  • Neurotoxicity – numbness / paraesthesia / weakness
  • Leukopaenia / anaemia / thrombocytopaenia
  • Nausea / vomiting / constipation / paralytic ileus
  • Alopecia