Venlafaxine
- OralVenlafaxineEffexor
Mechanism of Action
- Inhibits presynaptic reuptake of both serotonin and norepinephrine, resulting in greater concentrations within the synapse.
Clinical Use
- Indications
- Depression
- Generalised anxiety disorder
- Panic disorder
Contraindications
- Not for concurrent use with monoamine oxidase inhibitors (MAOi).
- Adverse Effects
- Fatigue
- Insomnia
- Dry mouth
- Weight loss / gain
- Dizziness / headache
- Nausea / vomiting / diarrhea
- Sexual dysfunction - decreased libido, ejaculatory disorders, erectile dysfunction
- Serotonin syndrome (when SNRIs given with MAOis / SSRIs) - confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis