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Vancomycin

  •  
    Oral / IV
    Vancomycin
    May be used in patients allergic to beta lactams
    • Mechanism of Action
    • Inhibits bacterial cell wall peptidoglycan synthesis.
    • Microbiology
    • Broad cover against gram positive organisms, including Methicillin resistant Staphylococcus aureus (MRSA).

Clinical Use

    • Indications
    • Proven MRSA
    • Life-threatening staphylococcal infections
    • Enterococcal endocarditis
    • Adverse Effects
    • Red man syndrome (vancomycin only) - immediate onset (4-10min after start of infusion) of pruritis and erythematous rash involving the face, neck and upper torso. Occurs when vancomycin is administered too rapidly.
    • Anaphylaxis
    • Nausea / vomiting / diarrhoea
    • Nephrotoxicity (rarely)
    • Monitoring
    • To ensure therapeutic levels, check serum concentration before the fourth dose.

Associated Adverse Effects
BETA

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