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Ustekinumab

  •  
    Subcut / IV
    Ustekinumab
    Stelara 
    • Mechanism of Action
    • A human monoclonal antibody directed against p40, a shared subunit present in both IL-12 and IL-23. Inhibition of IL-12 results in reduced differentiation of TH1 cells, while inhibition of IL-23 results in reduced induction of TH17 cells.

Clinical Use

    • Indications
    • Severe refractory Crohn’s disease
    • Refractory psoriatic arthritis
    • Moderate to severe plaque psoriasis
    • Adverse Effects
    • Injection site reactions
    • Upper respiratory tract infection
    • Dizziness
    • Headache
    • Nausea / vomiting / diarrhoea
    • Myalgias / arthralgias
    • Fatigue

Potential Indications
BETA

Psoriasis
Crohn's Disease
Psoriatic Arthritis
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