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Ustekinumab

 
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 View Topic Outline
  •  
    Subcut / IV
    Ustekinumab
    Stelara 

  • Mechanism of Action

  • A human monoclonal antibody directed against p40, a shared subunit present in both IL-12 and IL-23. Inhibition of IL-12 results in reduced differentiation of TH1 cells, while inhibition of IL-23 results in reduced induction of TH17 cells.

Clinical Use

  • Indications
  • Severe refractory Crohn’s disease
  • Refractory psoriatic arthritis
  • Moderate to severe plaque psoriasis
  • Adverse Effects
  • Injection site reactions
  • Upper respiratory tract infection
  • Dizziness
  • Headache
  • Nausea / vomiting / diarrhoea
  • Myalgias / arthralgias
  • Fatigue
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