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Urokinase

 
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  •  
    IV
    Urokinase
    Abbokinase 

  • Mechanism of Action

  • Activates plasminogen, resulting in its activation to plasmin and thus fibrinolysis.

Clinical Use

  • Indications

  • Pulmonary embolism with haemodynamic compromise, or massive pulmonary embolism.
  • Contraindications
  • Active bleeding
  • Recent GI / urinary bleeding
  • Recent major trauma / surgery
  • Recent ischaemic stroke
  • Intracranial haemorrhage, aneurysm, AVM or neoplasm
  • Current anticoagulant use
  • Pregnancy
  • Adverse Effects
  • Life-threatening haemorrhage
  • Hypersensitivity – rash, oedema, anaphylaxis
  • Cardiac arrhythmia
  • Hypotension
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