Urokinase | Drug Guide - MedSchool
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Urokinase

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    IV
    Urokinase
    Abbokinase 
    • Mechanism of Action
    • Activates plasminogen, resulting in its activation to plasmin and thus fibrinolysis.

Clinical Use

    • Indication
    • Pulmonary embolism with haemodynamic compromise, or massive pulmonary embolism.
    • Contraindications
    • Active bleeding
    • Recent GI / urinary bleeding
    • Recent major trauma / surgery
    • Recent ischaemic stroke
    • Intracranial haemorrhage, aneurysm, AVM or neoplasm
    • Current anticoagulant use
    • Pregnancy
    • Adverse Effects
    • Life-threatening haemorrhage
    • Hypersensitivity – rash, oedema, anaphylaxis
    • Cardiac arrhythmia
    • Hypotension
 
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