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Drug Guide
 
 

Trimethoprim + Sulfamethoxazole

 
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    Oral / IV
    Trimethoprim + Sulfamethoxazole
    Bactrim, Septrin 
    • Mechanism of Action
    • Trimethoprim inhibits the production of dihydrofolate reductase (DHFR), resulting in reduced conversion of dihydrofolic acid to active tetrahydrofolic acid - interfering with bacterial synthesis of nucleic acids. Sulfamethoxaole inhibits the production of dihydrofolate from para-aminobenzoic acid.
    • Microbiology

Clinical Use

    • Indications
    • Contraindications
    • Adverse Effects
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