Trimethoprim + Sulfamethoxazole
- Oral / IVTrimethoprim + SulfamethoxazoleBactrim, Septrin
- Mechanism of Action
- Trimethoprim inhibits the production of dihydrofolate reductase (DHFR), resulting in reduced conversion of dihydrofolic acid to active tetrahydrofolic acid - interfering with bacterial synthesis of nucleic acids. Sulfamethoxaole inhibits the production of dihydrofolate from para-aminobenzoic acid.
- Adverse Effects