- Mechanism of Action
- Inhibits the production of dihydrofolate reductase (DHFR), resulting in reduced conversion of dihydrofolic acid to active tetrahydrofolic acid - interfering with bacterial synthesis of nucleic acids.
- Active against most GI normal flora, the most common cause of UTI.
- Uncomplicated symptomatic urinary tract infection.
- Megaloblastic anaemia due to folate deficiency.
- Adverse Effects