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Drug Guide
 
 

Trimethoprim

 
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    Oral
    Trimethoprim
    Alprim 
    • Mechanism of Action
    • Inhibits the production of dihydrofolate reductase (DHFR), resulting in reduced conversion of dihydrofolic acid to active tetrahydrofolic acid - interfering with bacterial synthesis of nucleic acids.
    • Pharmacology
    • Microbiology
    • Active against most GI normal flora, the most common cause of UTI.

Clinical Use

    • Indication
    • Uncomplicated symptomatic urinary tract infection.
    • Contraindications
    • Megaloblastic anaemia due to folate deficiency.
    • Adverse Effects
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