Trimethoprim | Drug Guide - MedSchool
Sign up to start your free trial of MedSchool Premium!Get Started
 
Drug Guide
 
 
#
A
B
C
D
E
F
G
H
I
K
L
M
N
O
P
Q
R
S
T
U
V
W
Z
 

Trimethoprim

Bookmark
  •  
    Oral
    Trimethoprim
    Alprim 
    • Mechanism of Action
    • Inhibits the production of dihydrofolate reductase (DHFR), resulting in reduced conversion of dihydrofolic acid to active tetrahydrofolic acid - interfering with bacterial synthesis of nucleic acids.
    • Pharmacology
    • Higher affinity for bacterial dihydrofolate reductase than for human DHFR.
    • Mostly excreted unmetabolised into urine in high concentrations, resulting in its effect directly within the bladder.
    • Microbiology
    • Active against most GI normal flora, the most common cause of UTI.

Clinical Use

    • Indication
    • Uncomplicated symptomatic urinary tract infection.
    • Contraindications
    • Megaloblastic anaemia due to folate deficiency.
    • Adverse Effects
    • Rash / pruritis
    • Nausea / vomiting
    • Elevated LFTs
 
Feedback