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Drug Guide
 
 

Trastuzumab

 
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    IV infusion / Subcut
    Trastuzumab
    Herceptin 
     
    Inhibits ligand-independent HER signalling
    • Mechanism of Action
    • A monoclonal antibody directed against the HER2 receptor, which is involved in cell signalling and is overexpressed in certain cancers. Inhibition of HER2 signalling pathways results in cell cycle arrest; the monoclonal antibody also mediates antibody-dependent cell-mediated cytotoxicity.

Clinical Use

    • Indications
    • Contraindications
    • Left ventricular dysfunction, as evidenced by an LVEF <45%, or symptomatic heart failure.
    • Adverse Effects
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