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Topiramate

 
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  •  
    Oral
    Topiramate
    Topamax 

  • Mechanism of Action

  • Inhibits voltage-gated sodium channels and enhances GABA-mediated inhibition, resulting in suppression of seizure activity.

Clinical Use

  • Indications
  • Second-line therapy for partial (focal) seizures
  • Migraine prophylaxis
  • Adverse Effects
  • CNS disturbances – drowsiness, dizziness / ataxia, diplopia, tremor, cognitive slowing
  • Nausea / vomiting
  • Weight loss
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