Drug Guide
 

Topiramate

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    Oral
    Topiramate
    Topamax 
    • Mechanism of Action
    • Inhibits voltage-gated sodium channels and enhances GABA-mediated inhibition, resulting in suppression of seizure activity.

Clinical Use

    • Indications
    • Second-line therapy for partial (focal) seizures
    • Migraine prophylaxis
    • Adverse Effects
    • CNS disturbances – drowsiness, dizziness / ataxia, diplopia, tremor, cognitive slowing
    • Nausea / vomiting
    • Weight loss
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