MDI
Tiotropium
Spiriva
Long-acting – best for COPD maintenance
- Mechanism of Action
- Inhibits muscarinic (M3) receptors, leading to bronchial smooth muscle relaxation and bronchodilation through reduction in acetylcholine-mediated vagal tone.
Clinical Use
- Indications
- Acute asthma (ipratropium)
- Acute exacerbations of COPD (ipratropium)
- Maintenance therapy for COPD (tiotropium)
- Adverse Effects
- Dry mouth
- Headache
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