- IVTicarcillin-ClavulanateTimentinUsed for severe infections only
Mechanism of Action
- Ticarcillin is a beta lactam antibiotic that inhibits bacterial cell wall synthesis. Clavulanate is a a beta lactamase inhibitor that has no intrinsic antimicrobial activity but prevents breakdown of beta lactam by beta lactamase enzyme.
- Adverse Effects
- Hypersensitivity - urticarial rash, oedema, anaphylaxis
- GIT - nausea / vomiting / diarrhoea
- Thrombocytopaenia / leukopaenia