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Thyroxine

 
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  •  
    Oral
    Thyroxine
    Oroxine, Eutroxig 
     
    Adjust every 6-8 weeks according to TSH

  • Mechanism of Action

  • Synthetic T4 is converted to T3 that binds to nuclear thyroid hormone receptors, inducing alterations in gene transcription and subsequent effects on metabolism.

Clinical Use

  • Indications
  • Hypothyroidism
  • TSH-responsive thyroid tumours
  • Myxoedema coma
  • Adverse Effects
  • Thyrotoxicosis - palpitations, tachycardia, tachypnoea, fever, anxiety, headache, poor concentration
  • Nausea / vomiting / diarrhoea
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