Subcut
Teriparatide
Forteo
- Mechanism of Action
- Synthetic parathyroid hormone (PTH). Continuous PTH administration primarily stimulates osteoclast differentiation, while intermittent PTH administration (daily teriparatide) primarily stimulates osteoblast differentiation.
Clinical Use
- Indication
- Severe post-menopausal osteoporosis or osteoporosis in males, that is refractory to other medications.
- Contraindications
- Paget’s disease of bone
- Hypercalcaemia
- Malignancy
- Renal disease
- Adverse Effects
- Headache
- Hypertension
- Nausea / vomiting / diarrhea / constipation
- Arthralgia
- Dizziness
- Osteosarcoma (in rats)
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