Teriparatide

• Mechanism of Action
• Synthetic parathyroid hormone (PTH). Continuous PTH administration primarily stimulates osteoclast differentiation, while intermittent PTH administration (daily teriparatide) primarily stimulates osteoblast differentiation.

Clinical Use

• • Indication
  • Severe post-menopausal osteoporosis or osteoporosis in males, that is refractory to other medications.
• • Contraindications
  • Paget’s disease of bone
  • Hypercalcaemia
  • Malignancy
  • Renal disease
• • Adverse Effects
  • Headache
  • Hypertension
  • Nausea / vomiting / diarrhea / constipation
  • Arthralgia
  • Dizziness
  • Osteosarcoma (in rats)