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Teriparatide

 
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  •  
    Subcut
    Teriparatide
    Forteo 

  • Mechanism of Action

  • Synthetic parathyroid hormone (PTH). Continuous PTH administration primarily stimulates osteoclast differentiation, while intermittent PTH administration (daily teriparatide) primarily stimulates osteoblast differentiation.

Clinical Use

  • Indications

  • Severe post-menopausal osteoporosis or osteoporosis in males, that is refractory to other medications.
  • Contraindications
  • Paget’s disease of bone
  • Hypercalcaemia
  • Malignancy
  • Renal disease
  • Adverse Effects
  • Headache
  • Hypertension
  • Nausea / vomiting / diarrhea / constipation
  • Arthralgia
  • Dizziness
  • Osteosarcoma (in rats)
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