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Drug Guide
 
 

Tenecteplase

 
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    IV
    Tenecteplase
    Metalyse 
  • Mechanism of Action

  • Binds to fibrin on the clot surface and activate plasminogen, resulting in its activation to plasmin and thus fibrinolysis.

Clinical Use

  • Indications

  • ST elevation myocardial infarction, within 12 hours of onset of chest pain
  • Contraindications
  • Active bleeding
  • Recent GI / urinary bleeding
  • Recent major trauma / surgery
  • Recent ischaemic stroke
  • Intracranial haemorrhage, aneurysm, AVM or neoplasm
  • Current anticoagulant use
  • Pregnancy
  • Adverse Effects
  • Life-threatening haemorrhage
  • Hypersensitivity - rash, oedema, anaphylaxis
  • Cardiac arrhythmia
  • Hypotension
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