Tenecteplase
- IVTenecteplaseMetalyse
Mechanism of Action
- Binds to fibrin on the clot surface and activate plasminogen, resulting in its activation to plasmin and thus fibrinolysis.
Clinical Use
Indications
- ST elevation myocardial infarction, within 12 hours of onset of chest pain
- Contraindications
- Active bleeding
- Recent GI / urinary bleeding
- Recent major trauma / surgery
- Recent ischaemic stroke
- Intracranial haemorrhage, aneurysm, AVM or neoplasm
- Current anticoagulant use
- Pregnancy
- Adverse Effects
- Life-threatening haemorrhage
- Hypersensitivity - rash, oedema, anaphylaxis
- Cardiac arrhythmia
- Hypotension