Tenecteplase | Drug Guide - MedSchool
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Tenecteplase

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    IV
    Tenecteplase
    Metalyse 
    • Mechanism of Action
    • Binds to fibrin on the clot surface and activate plasminogen, resulting in its activation to plasmin and thus fibrinolysis.

Clinical Use

    • Indication
    • ST elevation myocardial infarction, within 12 hours of onset of chest pain
    • Contraindications
    • Active bleeding
    • Recent GI / urinary bleeding
    • Recent major trauma / surgery
    • Recent ischaemic stroke
    • Intracranial haemorrhage, aneurysm, AVM or neoplasm
    • Current anticoagulant use
    • Pregnancy
    • Adverse Effects
    • Life-threatening haemorrhage
    • Hypersensitivity – rash, oedema, anaphylaxis
    • Cardiac arrhythmia
    • Hypotension
 
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