IV
Teicoplanin
Alternative to vancomycin if severe red man syndrome
- Mechanism of Action
- Inhibits bacterial cell wall peptidoglycan synthesis.
- Microbiology
- Broad cover against gram positive organisms, including Methicillin resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase negative staphylococci.
Clinical Use
- Indications
- Proven MRSA
- Life-threatening staphylococcal infections
- Enterococcal endocarditis
- Adverse Effects
- Anaphylaxis
- Nausea / vomiting / diarrhoea
- Nephrotoxicity (rarely)
- Monitoring
- To ensure therapeutic levels, check serum concentration before the fourth dose.
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