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Drug Guide
 
 

Tacrolimus

 
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 View Topic Outline
  •  
    Oral / IV
    Tacrolimus
    Prograf 

  • Mechanism of Action

  • Inhibits T cell activation as well as transcription of IL-2 and other cytokines, through inhibition of calcineurin-mediated activation of NFAT.

Clinical Use

  • Indications

  • Prevention of graft rejection following kidney, liver or heart transplantation
  • Adverse Effects
  • Increased risk of infection (immunosuppression)
  • Fluid overload
  • Hypertension
  • Fevers
  • Hirsutism
  • LFT derangement
  • Renal impairment
  • Dyslipidaemia

  • Monitoring

  • Baseline and regular electrolytes, renal function, LFTs, FBC and lipids.
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