Tacrolimus | Drug Guide - MedSchool
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Tacrolimus

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    Oral / IV
    Tacrolimus
    Prograf 
    • Mechanism of Action
    • Inhibits T cell activation as well as transcription of IL-2 and other cytokines, through inhibition of calcineurin-mediated activation of NFAT.

Clinical Use

    • Indication
    • Prevention of graft rejection following kidney, liver or heart transplantation
    • Adverse Effects
    • Increased risk of infection (immunosuppression)
    • Fluid overload
    • Hypertension
    • Fevers
    • Hirsutism
    • LFT derangement
    • Renal impairment
    • Dyslipidaemia
    • Monitoring
    • Baseline and regular electrolytes, renal function, LFTs, FBC and lipids.
 
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