Oral / IV
Tacrolimus
Prograf
- Mechanism of Action
- Inhibits T cell activation as well as transcription of IL-2 and other cytokines, through inhibition of calcineurin-mediated activation of NFAT.
Clinical Use
- Indication
- Prevention of graft rejection following kidney, liver or heart transplantation
- Adverse Effects
- Increased risk of infection (immunosuppression)
- Fluid overload
- Hypertension
- Fevers
- Hirsutism
- LFT derangement
- Renal impairment
- Dyslipidaemia
- Monitoring
- Baseline and regular electrolytes, renal function, LFTs, FBC and lipids.
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