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Drug Guide

Suxamethonium / Succinylcholine

    IV / IM
    Suxamethonium / Succinylcholine

    • Mechanism of Action
    • Composed of two acetylcholine molecules joined at the acetate methyl group.
      Bind to nicotinic receptors, resulting in depolarization with opening of voltage-gated channels and muscle contraction. Voltage-gated sodium channels then close and are inactivated, while the membrane remains depolarized.
      Suxamethonium is not metabolized by acetylcholinesterase and therefore membrane depolarization is prolonged, resulting in prolonged inactivation of sodium channels and muscle relaxation.
      As the membrane remains depolarized, no further acetylcholine molecules are able to produce further depolarization.
    • Pharmacology

Clinical Use

    • Indications
    • Contraindications
    • Adverse Effects
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