Mechanism of Action
- Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.
- Many off-target effects due to inhibition of multiple targets.
- Advanced renal cell carcinoma
- Gastrointestinal stromal tumour (GIST) that has failed imatinib
- Unresectable, well-differentiated pancreatic neuroendocrine tumours
- Adverse Effects
- Hand-foot syndrome
- Cardiotoxicity - CCF, MI, thromboembolism, hypertension