Sunitinib

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    Oral
    Sunitinib
    Sutent 
    • Mechanism of Action
    • Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.
    • Pharmacology
    • Many off-target effects due to inhibition of multiple targets.

Clinical Use

    • Indications
    • Advanced renal cell carcinoma
    • Gastrointestinal stromal tumour (GIST) that has failed imatinib
    • Unresectable, well-differentiated pancreatic neuroendocrine tumours
    • Adverse Effects
    • Fatigue
    • Anorexia
    • Mucositis
    • Hand-foot syndrome
    • Cardiotoxicity - CCF, MI, thromboembolism, hypertension
    • Hypothyroidism
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