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Sunitinib

 
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  •  
    Oral
    Sunitinib
    Sutent 

  • Mechanism of Action

  • Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.

  • Pharmacology

  • Many off-target effects due to inhibition of multiple targets.

Clinical Use

  • Indications
  • Advanced renal cell carcinoma
  • Gastrointestinal stromal tumour (GIST) that has failed imatinib
  • Unresectable, well-differentiated pancreatic neuroendocrine tumours
  • Adverse Effects
  • Fatigue
  • Anorexia
  • Mucositis
  • Hand-foot syndrome
  • Cardiotoxicity - CCF, MI, thromboembolism, hypertension
  • Hypothyroidism
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