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Drug Guide
 
 

Sulfasalazine

 
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    Oral
    Sulfasalazine
    Salazopyrin 
     
    Not absorbed well – therefore most effective within the gut
  • Mechanism of Action

  • Inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, which results in increased adenosine release at the inflamed site. Adenosine binds to A2 receptors on inflammatory cells resulting in reduced inflammation.

Clinical Use

  • Indications
  • Acute episodes and maintenance of inflammatory bowel disease
  • Rheumatoid arthritis
  • Seronegative arthritis – reactive arthritis, psoriatic arthritis, anklyosing spondylitis
  • Adverse Effects
  • CNS - headache
  • Gastrointestinal - abdominal pain / nausea / vomiting / diarrhoea
  • Worsening of ulcerative colitis
  • Hepatotoxicity - elevated LFTs
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