Sulfasalazine
- OralSulfasalazineSalazopyrinNot absorbed well – therefore most effective within the gut
- Mechanism of Action
- Inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, which results in increased adenosine release at the inflamed site. Adenosine binds to A2 receptors on inflammatory cells resulting in reduced inflammation.
Clinical Use
- Indications
- Adverse Effects