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Spironolactone

  •  
    Oral
    Spironolactone
    Aldactone, Spiractin 
    • Mechanism of Action
    • Inhibits the action of aldosterone on sodium-potassium exchange pumps in the distal convoluted tubule.
    • Pharmacology
    • Potassium-sparing diuretics.

Clinical Use

    • Indications
    • Refractory hypertension
    • Refractory heart failure
    • Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
    • Symptomatic ascites
    • Maintenance therapy for hypokalaemia
    • Primary aldosteronism
    • Hirsutism
    • Adverse Effects
    • Gynaecomastia
    • Nausea / vomiting / cramping / diarrhoea
    • Fatigue
    • Hyperkalaemia

Potential Indications
BETA

Haemodynamic Dysfunction
Hyperaldosteronism
Cirrhosis
Hypokalaemia
Nephrotic Syndrome

Associated Adverse Effects
BETA

Electrolyte Abnormalities
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