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Drug Guide
 
 

Spironolactone

 
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    Oral
    Spironolactone
    Aldactone, Spiractin 
  • Mechanism of Action

  • Inhibits the action of aldosterone on sodium-potassium exchange pumps in the distal convoluted tubule.
  • Pharmacology

  • Potassium-sparing diuretics.

Clinical Use

  • Indications
  • Refractory hypertension
  • Refractory heart failure
  • Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
  • Symptomatic ascites
  • Maintenance therapy for hypokalaemia
  • Primary aldosteronism
  • Hirsutism
  • Adverse Effects
  • Gynaecomastia
  • Nausea / vomiting / cramping / diarrhoea
  • Fatigue
  • Hyperkalaemia
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