Mechanism of Action
- Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.
- Many off-target effects due to inhibition of multiple targets.
- Hepatocellular carcinoma
- Renal cell carcinoma
- Differentiated Thyroid cancer
- Adverse Effects
- Diarrhoea (particularly pazopanib)
- Hand-foot syndrome (sunitinib)
- Cardiotoxicity - CCF, MI, thromboembolism, hypertension