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Sorafenib

 
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  •  
    Oral
    Sorafenib
    Nexavar 

  • Mechanism of Action

  • Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.

  • Pharmacology

  • Many off-target effects due to inhibition of multiple targets.

Clinical Use

  • Indications
  • Hepatocellular carcinoma
  • Renal cell carcinoma
  • Differentiated Thyroid cancer
  • Adverse Effects
  • Fatigue
  • Anorexia
  • Mucositis
  • Diarrhoea (particularly pazopanib)
  • Hand-foot syndrome (sunitinib)
  • Cardiotoxicity - CCF, MI, thromboembolism, hypertension
  • Hypothyroidism
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