Drug Guide
 

Sorafenib

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    Oral
    Sorafenib
    Nexavar 
    • Mechanism of Action
    • Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.
    • Pharmacology
    • Many off-target effects due to inhibition of multiple targets.

Clinical Use

    • Indications
    • Hepatocellular carcinoma
    • Renal cell carcinoma
    • Differentiated Thyroid cancer
    • Adverse Effects
    • Fatigue
    • Anorexia
    • Mucositis
    • Diarrhoea (particularly pazopanib)
    • Hand-foot syndrome (sunitinib)
    • Cardiotoxicity - CCF, MI, thromboembolism, hypertension
    • Hypothyroidism
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