Drug Guide

Sodium Valproate

    Oral / IV
    Sodium Valproate
    Epilim, Valpro 
    • Mechanism of Action
    • Inhibits voltage-gated sodium channels, preventing propagation of action potentials and thus suppressing seizure activity. Also inhibits enzymes that breakdown GABA, resulting in increased GABA-mediated inhibition.

Clinical Use

    • Indications
    • Generalised seizures
    • Absence seizures
    • Acute mania
    • Maintenance therapy for bipolar disorder
    • Migraine prophylaxis
    • Adverse Effects
    • Nausea / vomiting / diarrhea
    • CNS disturbances – drowsiness, tremor
    • Thrombocytopaenia
    • Alopecia
    • Weight gain
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