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Drug Guide
 
 

Sodium Valproate

 
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  •  
    Oral / IV
    Sodium Valproate
    Epilim, Valpro 

  • Mechanism of Action

  • Inhibits voltage-gated sodium channels, preventing propagation of action potentials and thus suppressing seizure activity. Also inhibits enzymes that breakdown GABA, resulting in increased GABA-mediated inhibition.

Clinical Use

  • Indications
  • Generalised seizures
  • Absence seizures
  • Acute mania
  • Maintenance therapy for bipolar disorder
  • Migraine prophylaxis
  • Adverse Effects
  • Nausea / vomiting / diarrhea
  • CNS disturbances - drowsiness, tremor
  • Thrombocytopaenia
  • Alopecia
  • Weight gain
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