Sitagliptin

• Mechanism of Action
• Stimulates insulin secretion by inhibiting dipeptidyl peptidase-4 (DPP-4), an enzyme that normally degrades incretin hormones.
• • Pharmacology
  • Stimulates insulin secretion in hyperglycaemia, and Inhibits glucagon secretion in hyperglucagonaemia.

Clinical Use

• • Indication
  • Glycaemic control for type II diabetes
• • Adverse Effects
  • URTI
  • Headache
  • Pancreatitis