Sirolimus

• Mechanism of Action
• Forms a complex with FKBP-12 to inhibit mTOR, a key regulatory protein, and induces cell cycle arrest of T cells, B cells and other non-immune cells.

Clinical Use

• • Indication
  • Prevention of graft rejection following renal transplantation
• • Adverse Effects
  • Pancytopaenia
  • Infections (particularly respiratory and urinary tract)
  • Poor wound healing
  • Mouth ulcers
  • Male hypogonadism
  • Dyslipidaemia
  • Insomnia
  • Anxiety
  • Headache