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Drug Guide
 
 

Sirolimus

 
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    Oral
    Sirolimus
    Rapamune 
     
    Half-life ~60 hours
    • Mechanism of Action
    • Forms a complex with FKBP-12 to inhibit mTOR, a key regulatory protein, and induces cell cycle arrest of T cells, B cells and other non-immune cells.

Clinical Use

    • Indication
    • Prevention of graft rejection following renal transplantation
    • Adverse Effects
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