Sirolimus
- OralSirolimusRapamuneHalf-life ~60 hours
- Mechanism of Action
- Forms a complex with FKBP-12 to inhibit mTOR, a key regulatory protein, and induces cell cycle arrest of T cells, B cells and other non-immune cells.
Clinical Use
- Indication
- Prevention of graft rejection following renal transplantation
- Adverse Effects