Oral
Saxagliptin
Onglyza
Reduce dose in renal insufficiency
- Mechanism of Action
- Stimulates insulin secretion by inhibiting dipeptidyl peptidase-4 (DPP-4), an enzyme that normally degrades incretin hormones.
- Pharmacology
- Stimulates insulin secretion in hyperglycaemia, and Inhibits glucagon secretion in hyperglucagonaemia.
Clinical Use
- Indication
- Glycaemic control for type II diabetes
- Adverse Effects
- URTI
- Headache
- Pancreatitis
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