Drug Guide


    • Mechanism of Action
    • Directly inhibits factor Xa, resulting in reduced clot formation.
    • Pharmacology
    • Andexanet alpha may be used to reverse rivaroxaban in life-threatening situations only.

Clinical Use

    • Indications
    • Prevention of venous thromboembolism post hip / knee surgery
    • Treatment of venous thromboembolism (DVT / PE)
    • Non-valvular atrial fibrillation (prevention of stroke)
    • Contraindications
    • Active bleeding or risk of major bleeding
    • Use of other anticoagulants
    • Mechanical heart valve
    • Severe renal impairment (eGFR <30mL/min)
    • Severe hepatic disease with coagulopathy
    • Concurrent use of azole antimycotics
    • Adverse Effects
    • Haemorrhage
    • Nausea / vomiting
    • Monitoring
    • Anti-factor Xa assays may be used to assess for the therapeutic effect of rivaroxaban, though there are no established target levels.
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