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Rituximab

 
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 View Topic Outline
  •  
    IV / Subcut
    Rituximab
    Mabthera 

  • Mechanism of Action

  • A monoclonal antibody that targets CD20, a transmembrane protein on the surface of B cells, resulting in antibody-dependent and complement-dependent cytotoxicity.

Clinical Use

  • Indications
  • Rheumatoid arthritis
  • Granulomatosis with polyangiitis (GPA)
  • Microscopic polyangiitis (MPA)
  • Non-Hodgkin lymphoma (NHL)
  • Chronic lymphocytic leukaemia (CLL)
  • Adverse Effects
  • Bone marrow suppression - leucopaenia, anaemia, thrombocytopaenia
  • Injection site reactions
  • Progressive multifocal leukoencephalopathy (PML)
  • Nausea / vomiting
  • Angioedema
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