IV / Subcut
Rituximab
Mabthera
- Mechanism of Action
- A monoclonal antibody that targets CD20, a transmembrane protein on the surface of B cells, resulting in antibody-dependent and complement-dependent cytotoxicity.
Clinical Use
- Indications
- Rheumatoid arthritis
- Granulomatosis with polyangiitis (GPA)
- Microscopic polyangiitis (MPA)
- Non-Hodgkin lymphoma (NHL)
- Chronic lymphocytic leukaemia (CLL)
- Adverse Effects
- Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
- Injection site reactions
- Progressive multifocal leukoencephalopathy (PML)
- Nausea / vomiting
- Angioedema
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