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Rituximab

  •  
    IV / Subcut
    Rituximab
    Mabthera 
    • Mechanism of Action
    • A monoclonal antibody that targets CD20, a transmembrane protein on the surface of B cells, resulting in antibody-dependent and complement-dependent cytotoxicity.

Clinical Use

    • Indications
    • Rheumatoid arthritis
    • Granulomatosis with polyangiitis (GPA)
    • Microscopic polyangiitis (MPA)
    • Non-Hodgkin lymphoma (NHL)
    • Chronic lymphocytic leukaemia (CLL)
    • Adverse Effects
    • Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
    • Injection site reactions
    • Progressive multifocal leukoencephalopathy (PML)
    • Nausea / vomiting
    • Angioedema

Potential Indications
BETA

Haematologic Malignancy
Microscopic polyangiitis
Granulomatosis with Polyangiitis
Rheumatoid Arthritis

Associated Adverse Effects
BETA

Progressive Multifocal Leukencephalopathy
Progressive Multifocal Leukencephalopathy
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