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Drug Guide
 
 

Risperidone

 
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    Oral / IM
    Risperidone
    Risperdal 
     
    Available as depot – fortnightly dosing for schizophrenia
  • Mechanism of Action

  • Seems to cause transient antagonism of D2 receptors, as well as serotonin 5-HT2A antagonism.
  • Pharmacology

  • Less extrapyramidal adverse effects and less hyperprolactinaemia than first generation antipsychotics.

Clinical Use

  • Indications
  • Psychosis – schizophrenia, and related disorders
  • Acute mania
    Tranquilization – in the acute psychiatric setting
  • Agitation / hallucinations associated with delirium or dementia
  • Maintenance therapy for bipolar I disorder (low-dose)
  • Adverse Effects
  • Drowsiness
  • Postural hypotension
  • Prolonged QTc
  • Dyslipidaemia
  • Weight gain
  • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
  • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
  • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction
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