Risperidone

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    Oral / IM
    Risperidone
    Risperdal 
     
    Available as depot – fortnightly dosing for schizophrenia
    • Mechanism of Action
    • Seems to cause transient antagonism of D2 receptors, as well as serotonin 5-HT2A antagonism.
    • Pharmacology
    • Less extrapyramidal adverse effects and less hyperprolactinaemia than first generation antipsychotics.

Clinical Use

    • Indications
    • Psychosis – schizophrenia, and related disorders
    • Acute mania
      Tranquilization – in the acute psychiatric setting
    • Agitation / hallucinations associated with delirium or dementia
    • Maintenance therapy for bipolar I disorder (low-dose)
    • Adverse Effects
    • Drowsiness
    • Postural hypotension
    • Prolonged QTc
    • Dyslipidaemia
    • Weight gain
    • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
    • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
    • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction
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