Oral
Rimantadine
Flumadine
- Mechanism of Action
- Inhibit the ion channel function of M2 proteins on the viral membrane, preventing uncoating and disassembly of the virus once it enters cells.
- Microbiology
- Active against influenza A; no activity against influenza B.
Clinical Use
- Indication
- Influenza A prophylaxis.
- Adverse Effects
- Neuropsychiatric - dizziness, lethargy, ataxia, agitation, insomnia
- Palpitations
- Orthostatic hypotension
- Dry mouth
- Nausea / vomiting
- Constipation
- Livedo reticularis
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