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Drug Guide


    Oral / IV
  • Mechanism of Action

  • Inhibit bacterial RNA polymerase, resulting in disruption of DNA transcription.
  • Microbiology

  • Active against gram positive bacteria and Mycobacterium species.

Clinical Use

  • Indications
  • Mycobacteria - tuberculosis, Mycobacterium avium complex (MAC), leprosy
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Adverse Effects
  • Orange discolouration of bodily fluids
  • Hepatitis
  • Reflux
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