Oral
Ramipril
Tritace, Prilace
- Mechanism of Action
- Inhibits the ACE-driven conversion of angiotensin I to angiotensin II.
Causes vascular smooth muscle relaxation, reduced tubular sodium and water reabsorption, reduced aldosterone secretion, reduced ADH secretion and water retention, and increased bradykinin.
Clinical Use
- Indications
- Hypertension – first line management, especially in patients with chronic kidney disease or heart failure
- Heart failure
- Post myocardial infarction
- Contraindications
- Renal artery stenosis (precipitates renal failure)
- Pregnancy
- Adverse Effects
- Dry Cough (due to bradykinin)
- Hypotension
- Angioedema
- Hyperkalaemia
- Renal impairment
- Monitoring
- Electrolytes, urea and creatinine.
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