Oral / IV / IM
Quinine
Quinate
- Mechanism of Action
- Believed to inhibit haem polymerisation, resulting in a buildup of toxic haem molecules into non-toxic haemozoin within the food vacuole of plasmodia.
- Pharmacology
- G-6-PD deficiency
- Haemolytic anaemia
Clinical Use
- Indication
- Acute Plasmodium falciparum infection
- Contraindications
- G-6-PD deficiency
- Haemolytic anaemia
- Adverse Effects
- Cinchonism - tinnitus, deafness, headache, nausea / vomiting, visual disturbance
- Hypersensitivity - rash, oedema
- Hypoglycaemia
- Haemolysis
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