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Quinine

 
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 View Topic Outline
  •  
    Oral / IV / IM
    Quinine
    Quinate 

  • Mechanism of Action

  • Believed to inhibit haem polymerisation, resulting in a buildup of toxic haem molecules into non-toxic haemozoin within the food vacuole of plasmodia.
  • Pharmacology
  • G-6-PD deficiency
  • Haemolytic anaemia

Clinical Use

  • Indications

  • Acute Plasmodium  falciparum infection
  • Contraindications
  • G-6-PD deficiency
  • Haemolytic anaemia
  • Adverse Effects
  • Cinchonism - tinnitus, deafness, headache, nausea / vomiting, visual disturbance
  • Hypersensitivity - rash, oedema
  • Hypoglycaemia
  • Haemolysis
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