Drug Guide
 

Quetiapine

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    Oral
    Quetiapine
    Seroquel 
    • Mechanism of Action
    • Seems to cause transient antagonism of D2 receptors, as well as serotonin 5-HT2A antagonism.
    • Pharmacology
    • Less extrapyramidal adverse effects and less hyperprolactinaemia than first generation antipsychotics.

Clinical Use

    • Indications
    • Psychosis – schizophrenia, and related disorders
    • Acute mania
    • Maintenance therapy for bipolar I disorder (low-dose)
    • Adverse Effects
    • Drowsiness
    • Postural hypotension
    • Prolonged QTc
    • Dyslipidaemia
    • Weight gain
    • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
    • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
    • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction
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