Protamine Sulfate
- IVProtamine Sulfate
Mechanism of Action
- Binds to and inactivates heparin.
Pharmacology
- 1mg of protamine sulfate is expected to neutralize 100 units of heparin, though smaller doses should be given depending on time elapsed since heparin administration.
Clinical Use
- Indications
- Reversal of heparin-associated bleeding
- Reversal of heparin preoperatively or after renal dialysis
- Adverse Effects
- Bradycardia
- Hypotension
- Dypnoea
- Nausea / vomiting