Protamine Sulfate

• Mechanism of Action
• Binds to and inactivates heparin.
• • Pharmacology
  • 1mg of protamine sulfate is expected to neutralize 100 units of heparin, though smaller doses should be given depending on time elapsed since heparin administration.

Clinical Use

• • Indications
  • Reversal of heparin-associated bleeding
  • Reversal of heparin preoperatively or after renal dialysis
• • Adverse Effects
  • Bradycardia
  • Hypotension
  • Dypnoea
  • Nausea / vomiting