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Drug Guide

Protamine Sulfate

    Protamine Sulfate

  • Mechanism of Action

  • Binds to and inactivates heparin.
  • Pharmacology

  • 1mg of protamine sulfate is expected to neutralize 100 units of heparin, though smaller doses should be given depending on time elapsed since heparin administration.

Clinical Use

  • Indications
  • Reversal of heparin-associated bleeding
  • Reversal of heparin preoperatively or after renal dialysis
  • Adverse Effects
  • Bradycardia
  • Hypotension
  • Dypnoea
  • Nausea / vomiting
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