- Mechanism of Action
- Prevents utilization of iodine by the thyroid by inhibiting thyroperoxidase-catalysed iodination of tyrosine residues within the thyroid
- Suspected to have immunosuppressive effects by affecting signaling pathways between thyroid cells and T cells.
- Also inhibits conversion of T4 to T3.
- Hyperthyroidism, either as a sole agent or prior to surgery / radioiodine.
- Adverse Effects
- Neutropaenia / thrombocytopaenia
- Liver failure
- ANCA vasculitis