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Drug Guide
 
 

Propylthiouracil

 
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 View Topic Outline
  •  
    Oral
    Propylthiouracil
    PTU
  • Mechanism of Action
  • Prevents utilization of iodine by the thyroid by inhibiting thyroperoxidase-catalysed iodination of tyrosine residues within the thyroid
  • Suspected to have immunosuppressive effects by affecting signaling pathways between thyroid cells and T cells.
  • Also inhibits conversion of T4 to T3.

Clinical Use

  • Indications

  • Hyperthyroidism, either as a sole agent or prior to surgery / radioiodine.
  • Adverse Effects
  • Rash
  • Neutropaenia / thrombocytopaenia
  • Liver failure
  • ANCA vasculitis
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