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Propylthiouracil

  •  
    Oral
    Propylthiouracil
    PTU
    • Mechanism of Action
    • Prevents utilization of iodine by the thyroid by inhibiting thyroperoxidase-catalysed iodination of tyrosine residues within the thyroid
      Suspected to have immunosuppressive effects by affecting signaling pathways between thyroid cells and T cells.
      Also inhibits conversion of T4 to T3.

Clinical Use

    • Indication
    • Hyperthyroidism, either as a sole agent or prior to surgery / radioiodine.
    • Adverse Effects
    • Rash
    • Neutropaenia / thrombocytopaenia
    • Liver failure
    • ANCA vasculitis

Potential Indications
BETA

Thyrotoxicosis
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