Propofol

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    Propofol

    • Mechanism of Action
    • Augments the inhibitory action of GABA by decreasing the rate of dissociation of GABA from GABAA receptors.
    • Pharmacology
    • Highly lipophilic with slight water solubility, therefore formulated as a milky-white emulsion.
    • Three-compartment model of elimination
    • Onset <60 seconds
    • Duration 5 minutes

Clinical Use

    • Indications
    • Induction and maintenance of general anaesthesia
    • Sedation of ventilated patients in ICU
    • Adverse Effects
    • Hypotension (20-30% decrease)
    • Bradycardia
    • Involuntary movements
    • Apnoea
    • Reduced intracranial pressure
    • Propofol infusion syndrome – bradycardia, metabolic acidosis, rhabdomyolysis, hyperlipidaemia
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