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Drug Guide
 
 

Propofol

 
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    IV
    Propofol

  • Mechanism of Action

  • Augments the inhibitory action of GABA by decreasing the rate of dissociation of GABA from GABAA receptors.
  • Pharmacology
  • Highly lipophilic with slight water solubility, therefore formulated as a milky-white emulsion.
  • Three-compartment model of elimination
  • Onset <60 seconds
  • Duration 5 minutes

Clinical Use

  • Indications
  • Induction and maintenance of general anaesthesia
  • Sedation of ventilated patients in ICU
  • Adverse Effects
  • Hypotension (20-30% decrease)
  • Bradycardia
  • Involuntary movements
  • Apnoea
  • Reduced intracranial pressure
  • Propofol infusion syndrome – bradycardia, metabolic acidosis, rhabdomyolysis, hyperlipidaemia
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