Procainamide

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    Oral / IV
    Procainamide

    • Mechanism of Action
    • Binds to and inhibits fast sodium channels responsible for rapid depolarisation during phase 0 of the cardiomyocyte action potential.
    • Pharmacology
    • Acts on cardiomyocytes, with no action on pacemaker cells whose phase 0 is mediated by calcium influx. Moderate sodium channel blockade, but increases the absolute refractory period (ARP).

Clinical Use

    • Indications
    • Cardioversion of atrial fibrillation / flutter
    • Acute ventricular tachycardia
    • Adverse Effects
    • Anticholinergic - dry mouth, blurred vision, constipation, urinary retention
    • Nausea / vomiting / diarrhoea
    • Headache
    • Fatigue
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