- Oral / IVProcainamide
- Mechanism of Action
- Binds to and inhibits fast sodium channels responsible for rapid depolarisation during phase 0 of the cardiomyocyte action potential.
- Acts on cardiomyocytes, with no action on pacemaker cells whose phase 0 is mediated by calcium influx. Moderate sodium channel blockade, but increases the absolute refractory period (ARP).
- Adverse Effects