×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Drug Guide
 
 

Procainamide

 
Bookmark
 View Topic Outline
  •  
    Oral / IV
    Procainamide

  • Mechanism of Action

  • Binds to and inhibits fast sodium channels responsible for rapid depolarisation during phase 0 of the cardiomyocyte action potential.

  • Pharmacology

  • Acts on cardiomyocytes, with no action on pacemaker cells whose phase 0 is mediated by calcium influx. Moderate sodium channel blockade, but increases the absolute refractory period (ARP).

Clinical Use

  • Indications
  • Cardioversion of atrial fibrillation / flutter
  • Acute ventricular tachycardia
  • Adverse Effects
  • Anticholinergic - dry mouth, blurred vision, constipation, urinary retention
  • Nausea / vomiting / diarrhoea
  • Headache
  • Fatigue
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now
   
 
 

Snapshot: Initialising...