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Drug Guide
 
 

Procainamide

 
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 View Topic Outline
  •  
    Oral / IV
    Procainamide

  • Mechanism of Action

  • Binds to and inhibits fast sodium channels responsible for rapid depolarisation during phase 0 of the cardiomyocyte action potential.

  • Pharmacology

  • Acts on cardiomyocytes, with no action on pacemaker cells whose phase 0 is mediated by calcium influx. Moderate sodium channel blockade, but increases the absolute refractory period (ARP).

Clinical Use

  • Indications
  • Cardioversion of atrial fibrillation / flutter
  • Acute ventricular tachycardia
  • Adverse Effects
  • Anticholinergic - dry mouth, blurred vision, constipation, urinary retention
  • Nausea / vomiting / diarrhoea
  • Headache
  • Fatigue
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