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Drug Guide
 
 

Primaquine

 
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  •  
    Oral
    Primaquine
    Primacin 

  • Mechanism of Action

  • Unknown.

  • Microbiology

  • Effective against Plasmodium vivax and ovale as they enter a dormant phase in the liver.

Clinical Use

  • Indications
  • Elimination of intrahepatic Plasmodium vivax and ovale, once erythrocytic forms have been eradicated by a blood schizonticide.
  • Elimination of Plasmodium falciparum gametocytes, once erythrocytic forms have been eradicated by a blood schizonticide.
  • Contraindications
  • Pregnancy
  • G-6-P deficiency
  • Active rheumatoid arthritis or lupus
  • Adverse Effects
  • Nausea / vomiting
  • Haemolysis
  • Methaemoglobinaemia
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