Prazosin
- OralPrazosinMinipress
Mechanism of Action
- Blocks α1-adrenoceptors, resulting in arteriolar smooth muscle relaxation and reduced peripheral resistance.
Pharmacology
- Short acting. Safe for use in patients with impaired renal function.
Clinical Use
- Indications
- Hypertension - second line therapy, especially indicated for patients with benign prostatic hyperplasia
- Severe congestive cardiac failure
- Benign prostatic hyperplasia
- Contraindications
- Renal artery stenosis (precipitates renal failure)
- Pregnancy
- Hyperkalaemia
- Adverse Effects
- Postural hypotension
- Retrograde ejaculation (due to effect on prostate)
Monitoring
- Electrolytes, urea and creatinine.