Drug Guide
 

Prazosin

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    Oral
    Prazosin
    Minipress 
    • Mechanism of Action
    • Blocks α1-adrenoceptors, resulting in arteriolar smooth muscle relaxation and reduced peripheral resistance.
    • Pharmacology
    • Short acting. Safe for use in patients with impaired renal function.

Clinical Use

    • Indications
    • Hypertension – second line therapy, especially indicated for patients with benign prostatic hyperplasia
    • Severe congestive cardiac failure
    • Benign prostatic hyperplasia
    • Contraindications
    • Renal artery stenosis (precipitates renal failure)
    • Pregnancy
    • Hyperkalaemia
    • Adverse Effects
    • Postural hypotension
    • Retrograde ejaculation (due to effect on prostate)
    • Monitoring
    • Electrolytes, urea and creatinine.
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